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KMID : 0366220060410040317
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Korean Journal of Hematology
2006 Volume.41 No. 4 p.317 ~ p.320
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Autoimmune Hemolytic Anemia in Myelodysplastic Syndrome
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Shim Kwang-Yeon
Roh Mi-Oh
Kim Hyun-Jung
Bae Sang-Byung
Kim Chan-Kyu
Lee Kyu-Taek
Lee You-Kyoung
Park Sung-Kyu
Won Jong-Ho
Park Hee-Sook
Hong Dae-Sik
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Abstract
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Autoimmune paraneoplastic syndromes are encountered in patients with myelodysplastic syndromes. A review of case reports suggested 10% of myelodysplastic syndrome patients may experience various autoimmune syndromes, associated with immunological-mediated hematologic abnormalities, such as Coombs’ negative hemolytic anemia. In patients with myelodysplastic syndrome, Coombs’ negative hemolytic anemia may be underdiagnosed due to its association with reticulocytopenia. Therefore, the findings from a peripheral blood smear and measurement of haptoglobin level are important. Autoimmune manifestations respond to immunosuppressive agents, including steroids. Herein, a case with Coombs’ negative hemolytic anemia, diagnosed with myelodysplastic syndrome from a bone marrow biopsy, is reported, with a review of the previously reported literature.
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KEYWORD
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Myelodysplastic syndrome, Autoimmune, Hemolytic anemia
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